Informatics Publishing Limited

M. N. Dahake ¹, P. P. Wattamwar ², R. A. Bongirwar ², D. S. Mohale ², R. L. Bakal ², A. V. Chandewar ²

Affiliations
1 P. Wadhwani College of Pharmacy, Yavatmal (M.S.), IN
2 P. Wadhwani College of Pharmacy, Yavatmal (M.S.), IN

Abstract

Oral delivery of drug is the most preferable route of drug delivery due to ease of administration, patient compliance and flexibility in formulation etc. However, it is a well accepted fact that it is difficult to predict the real in vivo time of release with solid, oral controlled release dosage forms. Various attempts have been made to prolong the retention time of the dosage form in the stomach. One such approach is development of floating Microspheres involves preparation of a device that remains buoyant in the stomach contents due to its lower density than that of the gastric fluids.Floating microspheres are gastro-retentive drug delivery systems based on non-effervescent approach. These microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers, ideally having a size less than 200 micrometer. Floating microspheres are prepared by solvent diffusion and evaporation methods to create the hollow inner core. Floating microspheres are specially gaining attention due to their wide applicability in the targeting of drugs to stomach.

Keywords

Oral Controlled Release Dosage Form, Retention Time, Floating Microsphere.

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N. I. Kochar ¹, M. N. Dahake ¹, R. L. Bakal ¹, A. P. Devani ¹, A. V. Chandewar ¹

Affiliations
1 Department of Quality Assurance, P.W. College of Pharmacy, Dhamangaon Road, Yavatmal, 445001, IN

Abstract

A simple isocratic RP-HPLC method has been developed and subsequently validated for the determination of Ramipril and Amlodipine Besylate in pharmaceutical dosage forms within very short retention time. The method employs an Xterra C18 column, 5 μ, 150 mm x 4.60 mm id with flow rate of 1.5 ml/min using UV detection at 210nm. The separation was carried out using a mobile phase consisting of Sodium Lauryl Sulfate buffer by adjusting pH 2.5 and final composition is Buffer: Acetonitrile: Methanol (45:16.5:38.5)V/V. The retention time for Ramipril and Amlodipine Besylate was found to be 3.1 minutes and 3.8 minutes respectively. The results of analysis were validated statically and by recovery studies. Hence the proposed method was found to be accurate, precise, reproducible and specific and can be used for simultaneous analysis of these drugs in tablet formulation.

Keywords

RP-HPLC, Sodium Lauryl Sulfate Buffer, Ramipril, Amlodipine Besylate.

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